3288 EEA1 (C45B10) Rabbit mAb #3288

"上海博耀生物销售EEA1 (C45B10) Rabbit mAb #3288，CST原装品质，价格优惠，订购EEA1 (C45B10) Rabbit mAb #3288，详情请咨询销

"上海博耀生物销售EEA1 (C45B10) Rabbit mAb #3288，CST原装品质，价格优惠，订购EEA1 (C45B10) Rabbit mAb #3288，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：EEA1 (C45B10) Rabbit mAb #3288
货号：3288
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3288P	40 ul (4 western blots)	询价
3288S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IF-IC	H M R	Endogenous	170	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： EEA1 (C45B10) Rabbit mAb detects endogenous levels of total EEA1 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser70 of human EEA1 protein.
抗体背景：

EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking (1-2). The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes (3). The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin (4-6). Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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