3281 Phospho-FAK (Tyr576/577) Antibody #3281

"上海博耀生物销售Phospho-FAK (Tyr576/577) Antibody #3281，CST原装品质，价格优惠，订购Phospho-FAK (Tyr576/577) Antibody #

"上海博耀生物销售Phospho-FAK (Tyr576/577) Antibody #3281，CST原装品质，价格优惠，订购Phospho-FAK (Tyr576/577) Antibody #3281，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-FAK (Tyr576/577) Antibody #3281
货号：3281
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3281P	40 ul (4 western blots)	询价
3281S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R (C) (X)	Endogenous	125	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  C=Chicken  X=Xenopus
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-FAK (Tyr576/577) Antibody detects endogenous levels of FAK only when phosphorylated at tyrosine 576/577. This antibody may cross-react with other activated receptor tyrosine kinases.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr576/577 of human FAK. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival (1). Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ (2-5). Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK (6,7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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