3279 Shootin1 Antibody #3279

"上海博耀生物销售Shootin1 Antibody #3279，CST原装品质，价格优惠，订购Shootin1 Antibody #3279，详情请咨询销售人员！产品详

"上海博耀生物销售Shootin1 Antibody #3279，CST原装品质，价格优惠，订购Shootin1 Antibody #3279，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Shootin1 Antibody #3279
货号：3279
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3279S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R	Endogenous	60	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Shootin1 Antibody detects endogenous levels of total shootin1 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding Lys450 of human shootin1. Antibodies are purified by peptide affinity chromatography.
抗体背景：

The differentiation process of neurons can be divided into five stages, each stage characterized by morphological changes observed in the developing cells. In stage 1, the cells extend lamellipodia and in stage 2 their lamellipodia develop into immature neurites. In stage 3 one neurite elongates rapidly to form an axon and in stage 4 the remaining immature neuritis elongate to form dendrites. In stage 5 synaptic contacts are formed and a neuronal network is established (1).Shootin1 is involved in generating internal asymmetric signals required for neuronal during stages 2 and 3. The extension of an axon requires considerable reorganization of the cytoskeleton mediated by PI3K/Akt and PI3K/Cdc42 signaling (1). Shootin1 is involved in regulating the subcellular localization of PI3 kinase. Furthermore, shootin1 is upregulated during polarization and accumulates asymmetrically in a single neurite that consequently elongates rapidly to form an axon (2).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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