3268 Notch1 (C44H11) Rabbit mAb #3268

"上海博耀生物销售Notch1 (C44H11) Rabbit mAb #3268，CST原装品质，价格优惠，订购Notch1 (C44H11) Rabbit mAb #3268，详情请咨

"上海博耀生物销售Notch1 (C44H11) Rabbit mAb #3268，CST原装品质，价格优惠，订购Notch1 (C44H11) Rabbit mAb #3268，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Notch1 (C44H11) Rabbit mAb #3268
货号：3268
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3268S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H (M) (R)	Endogenous	120, 300	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Notch1 (C44H11) Rabbit mAb detects endogenous levels of total Notch1 protein. It recognizes both the full-length (~ 300 kDa) and the transmembrane/intracellular region NTM (~120 kDa).
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro2439 of human Notch1.
抗体背景：

Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) (2). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes (3-4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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