3251 Phospho-Caveolin-1 (Tyr14) Antibody #3251

"上海博耀生物销售Phospho-Caveolin-1 (Tyr14) Antibody #3251，CST原装品质，价格优惠，订购Phospho-Caveolin-1 (Tyr14) Antibo

"上海博耀生物销售Phospho-Caveolin-1 (Tyr14) Antibody #3251，CST原装品质，价格优惠，订购Phospho-Caveolin-1 (Tyr14) Antibody #3251，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Caveolin-1 (Tyr14) Antibody #3251
货号：3251
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3251P	40 ul (4 western blots)	询价
3251S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R Mk (Dg)	Endogenous	23, 25	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  Dg=Dog
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Caveolin-1 (Tyr14) Antibody detects endogenous levels of caveolin-1 only when phosphorylated at tyrosine 14. The antibody does not cross-react with caveolin-2, -3 or caveolin-1beta, the short isoform of caveolin-1.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr14 of human caveolin-1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The 21-24 kDa integral proteins, caveolins, are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homooligomers that interact with cholesterol and other lipids (1). Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease (2). Caveolins interact with multiple signaling molecules, such as Gα subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS (1,2). It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins, such as GRB7 (3-5). Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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