3247 Pim-1 (C93F2) Rabbit mAb #3247

"上海博耀生物销售Pim-1 (C93F2) Rabbit mAb #3247，CST原装品质，价格优惠，订购Pim-1 (C93F2) Rabbit mAb #3247，详情请咨询销

"上海博耀生物销售Pim-1 (C93F2) Rabbit mAb #3247，CST原装品质，价格优惠，订购Pim-1 (C93F2) Rabbit mAb #3247，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Pim-1 (C93F2) Rabbit mAb #3247
货号：3247
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3247P	40 ul (4 western blots)	询价
3247S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M (R) (Mk) (B)	Endogenous	34	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Pim-1 (C93F2) Rabbit mAb detects endogenous levels of total Pim-1 protein. No cross reactivity was detected with other Pim family members.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val160 of Pim-1.
抗体背景：

Pim proteins (Pim-1, Pim-2 and Pim-3) are oncogene-encoded serine/threonine kinases (1). Pim-1, a serine/threonine kinase highly expressed in hematopoietic cells, plays a critical role in the transduction of mitogenic signals and is rapidly induced by a variety of growth factors and cytokines (1-4). Pim-1 cooperates with c-Myc in lymphoid cell transformation and protects cells from growth factor withdrawal and genotoxic stress-induced apoptosis (5,6). Pim-1 also enhances the transcriptional activity of c-Myb through direct phosphorylation within the c-Myb DNA binding domain as well as phosphorylation of the transcriptional coactivator p100 (7,8). Hypermutations of the Pim-1 gene are found in B-cell diffuse large cell lymphomas (9). Phosphorylation of Pim-1 at Tyr218 by Etk occurs following IL-6 stimulation and correlates with an increase in Pim-1 activity (10). Various Pim substrates have been identified; Bad is phosphorylated by both Pim-1 and Pim-2 at Ser112 and this phosphorylation reverses Bad-induced cell apoptosis (11,12).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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