3216 Dvl2 Antibody #3216

"上海博耀生物销售Dvl2 Antibody #3216，CST原装品质，价格优惠，订购Dvl2 Antibody #3216，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售Dvl2 Antibody #3216，CST原装品质，价格优惠，订购Dvl2 Antibody #3216，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Dvl2 Antibody #3216
货号：3216
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3216S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R Hm Mk Mi	Endogenous	90 to 95	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Hm=Hamster  Mk=Mon key  Mi=Mink
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Dvl2 Antibody detects endogenous levels of total Dvl2 protein. It does not cross-react with Dvl3.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser638 of human Dvl2. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3β promoting β-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK (1,2). There are three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated (3) and accumulate in the nucleus (4). Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes (5) and mediate endocytosis of the Fzd receptor after Wnt protein stimulation (6). Overexpression of Dvl has been reported in certain cancers (7,8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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