3201 Yes Antibody #3201

"上海博耀生物销售Yes Antibody #3201，CST原装品质，价格优惠，订购Yes Antibody #3201，详情请咨询销售人员！产品详细参数如下

"上海博耀生物销售Yes Antibody #3201，CST原装品质，价格优惠，订购Yes Antibody #3201，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Yes Antibody #3201
货号：3201
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3201S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H Mk B	Endogenous	60	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  Mk=Mon key  B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Yes Antibody detects endogenous levels of total Yes protein. This antibody does not cross-react with Src.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Yes protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The cellular oncogene c-Yes and its viral homologue v-Yes (the transforming gene of Yamaguchi 73 and Esh avian sarcoma viruses) encode a 60 kDa, cytoplasmic, membrane-associated, protein-tyrosine kinase (1). Yes belongs to the Src kinase family and is ubiquitously expressed in many tissues and cells. Like other Src family members, Yes contains several conserved functional domains such as an N-terminal myristoylation sequence for membrane targeting, SH2 and SH3 domains, a kinase domain, and a C-terminal non-catalytic domain (2). Although several lines of evidence support redundancy in signaling between Yes and other Src family kinases, there is also a growing body of evidence indicating specificity in Yes signaling (2). Yes is activated downstream of a multitude of cell surface receptors, including receptor tyrosine kinases, G protein-coupled receptors, and cytokine receptors (3). In addition, both Yes and Src kinases are activated during the cell cycle transition from G2 to M phase (3). Investigators have found that dysfunction of Yes is associated with the development of various cancers (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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