3189 Fatty Acid Synthase Antibody #3189

"上海博耀生物销售Fatty Acid Synthase Antibody #3189，CST原装品质，价格优惠，订购Fatty Acid Synthase Antibody #3189，详情

"上海博耀生物销售Fatty Acid Synthase Antibody #3189，CST原装品质，价格优惠，订购Fatty Acid Synthase Antibody #3189，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Fatty Acid Synthase Antibody #3189
货号：3189
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3189S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M	Endogenous	273	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Fatty Acid Synthase Antibody detects endogenous levels of total fatty acid synthase protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide around Ala1160 corresponding to a sequence of mouse fatty acid synthase. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Fatty acid synthase (FASN) catalyzes the synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA. FASN is active as a homodimer with seven different catalytic activities and produces lipids in the liver for export to metabolically active tissues or storage in adipose tissue. In most other human tissues, FASN is minimally expressed since they rely on circulating fatty acids for new structural lipid synthesis (1).Recently, increased expression of FASN has emerged as a phenotype common to most human carcinomas. In breast cancer, immunohistochemical staining showed that the levels of FASN are directly related to the size of breast tumors (2). Studies also showed that FASN is highly expressed in lung and prostate cancers and that FASN expression is an indicator of poor prognosis in breast and prostate cancer (3-5). Furthermore, inhibition of FASN is selectively cytotoxic to human cancer cells (5). Thus, increased interest has focused on FASN as a potential target for the diagnosis and treatment of cancer as well as metabolic syndrome (6,7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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