3177 BiP (C50B12) Rabbit mAb #3177

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"上海博耀生物销售BiP (C50B12) Rabbit mAb #3177，CST原装品质，价格优惠，订购BiP (C50B12) Rabbit mAb #3177，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：BiP (C50B12) Rabbit mAb #3177
货号：3177
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： BiP
规格：

No.	Size	Price
3177P	40 ul (4 western blots)	询价
3177S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IHC-P IHC-F	H M	Endogenous	78	Rabbit IgG

Applications Key:  W=Western Blotting  IHC-P=Immunohistochemistry (Paraffin)  IHC-F=Immunohistochemistry (Frozen)
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： BiP (C50B12) Rabbit mAb detects endogenous levels of total BiP protein.
来源及纯化方法： BiP (C50B12) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding Gly584 of human BiP.
抗体背景：

Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER). Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including BiP. BiP was identified as an immunoglobulin heavy chain binding protein in pre-B cells (1,2). It was also found to be induced at the protein level by glucose starvation (3). When protein folding is disturbed inside ER, BiP synthesis is increased. Subsequently, BiP binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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