3155 Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb #3155

"上海博耀生物销售Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb #3155，CST原装品质，价格优惠，订购Phospho-M-CSF Rece

"上海博耀生物销售Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb #3155，CST原装品质，价格优惠，订购Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb #3155，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb #3155
货号：3155
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3155S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P F	H M	Endogenous	175	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb detects endogenous levels of M-CSF receptor only when phosphorylated at tyrosine 723. The antibody does not cross-react with related active protein tyrosine kinases.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr723 of human M-CSF receptor.
抗体背景：

Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. M-CSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. (1-3). Binding of M-CSF to its receptor induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins (4). There are at least five major tyrosine autophosphorylation sites. Tyr723 (Tyr721 in mouse) is located in the kinase insert (KI) region. Phosphorylated Tyr723 binds the p85 subunit of PI3 kinase as well as PLC-γ 2 (5). Phosphorylation of Tyr809 provides a docking site for Shc (5). Overactivation of this receptor can lead to a malignant phenotype in various cell systems (6). The activated M-CSF receptor has been shown to be a predictor of poor outcome in advanced epithelial ovarian carcinoma (7) and breast cancer (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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