3115 IFN-α (8C21) Mouse mAb #3115

"上海博耀生物销售IFN-α (8C21) Mouse mAb #3115，CST原装品质，价格优惠，订购IFN-α (8C21) Mouse mAb #3115，详情请咨询销售

"上海博耀生物销售IFN-α (8C21) Mouse mAb #3115，CST原装品质，价格优惠，订购IFN-α (8C21) Mouse mAb #3115，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：IFN-α (8C21) Mouse mAb #3115
货号：3115
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
3115S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H	Recombinant	19	Mouse IgG1

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： IFN-α (8C21) Mouse mAb detects recombinant human interferon-α protein. This antibody does not cross-react with human interferon-β and -γ.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with purified natural human interferon-α proteins.
抗体背景：

Interferons (IFNs) appear both locally and systematically early after viral infection and participate in limiting the spread of infection. They also affect cell differentiation, growth, surface antigen expression and immunoregulation (1). There are three naturally occurring interferons: α, β and γ. IFN-α is derived from lymphoblastic tissue and has a number of therapeutic applications in the treatment of various human cancers and diseases of viral origin. Recombinant IFN-α from both natural and synthetic genes binds to a common cell surface receptor and induces antiviral activity in a variety of cell lines. When binding to discrete cell surface receptors on target cells, IFN-α induces rapid changes in Jak/Stat phosphorylation, which initiates the Jak/Stat signaling pathway (2). IFN-α signaling also involves production of DAG without an increased intracellular free calcium concentration and the subsequent activation of calcium-independent isoforms of PKC (β and ε) (3). All IFN-α signaling pathways lead to final alterations of gene expression, which mediate their pleiotropic biologic activities.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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