3104 Phospho-Smad2 (Ser245/250/255) Antibody #3104

"上海博耀生物销售Phospho-Smad2 (Ser245/250/255) Antibody #3104，CST原装品质，价格优惠，订购Phospho-Smad2 (Ser245/250/255

"上海博耀生物销售Phospho-Smad2 (Ser245/250/255) Antibody #3104，CST原装品质，价格优惠，订购Phospho-Smad2 (Ser245/250/255) Antibody #3104，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Smad2 (Ser245/250/255) Antibody #3104
货号：3104
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3104S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M (R)	Endogenous	60	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Smad2 (Ser245/250/255) Antibody detects endogenous levels of Smad2 only when phosphorylated at serines 245, 250 or 255.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding serines 245/250/255 of Smad2. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 (1-5). Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses (6-8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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