3103 Smad2 (L16D3) Mouse mAb #3103

"上海博耀生物销售Smad2 (L16D3) Mouse mAb #3103，CST原装品质，价格优惠，订购Smad2 (L16D3) Mouse mAb #3103，详情请咨询销售

"上海博耀生物销售Smad2 (L16D3) Mouse mAb #3103，CST原装品质，价格优惠，订购Smad2 (L16D3) Mouse mAb #3103，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Smad2 (L16D3) Mouse mAb #3103
货号：3103
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
3103S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R Mk	Endogenous	60	Mouse IgG1

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Smad2 (L16D3) Mouse mAb detects endogenous levels of total Smad2 protein and may detect Smad3 due to high sequence homology.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human Smad2 protein.
抗体背景：

Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 (1-5). Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses (6-8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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