3072 PKR Antibody #3072

"上海博耀生物销售PKR Antibody #3072，CST原装品质，价格优惠，订购PKR Antibody #3072，详情请咨询销售人员！产品详细参数如下

"上海博耀生物销售PKR Antibody #3072，CST原装品质，价格优惠，订购PKR Antibody #3072，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PKR Antibody #3072
货号：3072
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3072S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H	Endogenous	74	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： PKR Antibody detects endogenous levels of PKR. This antibody does not cross-react with other related proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr451 of human PKR. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Protein kinase R (PKR) is transcriptionally induced by interferon and activated by double-stranded RNA (dsRNA). PKR inhibits translation initiation through phosphorylation of the α subunit of the initiation factor eIF2 (eIF2α) and also controls the activation of several transcription factors, such as NF-κB, p53, and the Stats. In addition, PKR mediates apoptosis induced by many different stimuli, such as LPS, TNF-α, viral infection, and serum starvation (1,2). Activation of PKR by dsRNA results in PKR dimerization and autophosphorylation of Thr446 and Thr451 in the activation loop. Substitution of threonine for alanine at position 451 completely inactivated PKR, while a mutant with a threonine to alanine substitution at position 446 was partially active (3). Research studies have implicated PKR activation in the pathologies of neurodegenerative diseases, including Alzheimer's disease (4,5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-PCDHB7原钙粘蛋白β7抗体
ab103205/Anti-CDH20 antibody
Anti-Neurexin 1轴突蛋白1(Neurexin 1α)抗体
Anti-NEGR1神经生长调节蛋白1抗体
ab101036/Anti-GABA A Receptor gamma 2 antibody
ab101776/Anti-Calbindin antibody
ab101359/Anti-CTTNBP2NL antibody
ab102786/Anti-eIF2A antibody
ab102083/Anti-ADH5 antibody
ab101530/Anti-CD4 antibody
Anti-Cyclin A2/CCN1周期素A2抗体
ab103461/Anti-DGCR6 antibody
Anti-GluR1/AMPA谷氨酸受体1抗体
ab103357/Anti-Cirhin antibody
ab103221/Anti-C9orf40 antibody
ab100801/Anti-EBAG9 antibody"
本页产品地址：http://www.geilan.com/sell/show-3244826.html