3070 Phospho-IRS-1 (Tyr895) Antibody #3070

"上海博耀生物销售Phospho-IRS-1 (Tyr895) Antibody #3070，CST原装品质，价格优惠，订购Phospho-IRS-1 (Tyr895) Antibody #3070

"上海博耀生物销售Phospho-IRS-1 (Tyr895) Antibody #3070，CST原装品质，价格优惠，订购Phospho-IRS-1 (Tyr895) Antibody #3070，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-IRS-1 (Tyr895) Antibody #3070
货号：3070
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3070S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H (M) (R)	Transfected Only	180	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-IRS-1 (Tyr895) Antibody detects transfected levels of IRS-1 only when phosphorylated at Tyr895. The antibody may cross-react with other activated receptor tyrosine kinases (RTKs) and docking proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr896 of human IRS-1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin (2-4). IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK (5) and IKK (6) while Ser789 is phosphorylated by SIK-2, a member of the AMPK family (7). The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively (8,9). Phosphorylation of IRS-1 at Ser1101 is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity (10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-AT1R/AGTR1血管紧张素Ⅱ-1型受体抗体
Anti-Cullin/C10orf46CULLIN抗体
Anti-VAT1L/KIAA1576突触小泡膜蛋白同源样蛋白1抗体
Anti-PCDH20原钙粘附蛋白20抗体
ab103666/Anti-EPDR1 antibody
Anti-Transthyretin转甲状腺素蛋白抗体
ab10053/Anti-D-Dimer antibody
ab101829/Anti-BPIL3 antibody
ab102653/Anti-FKSG14 antibody
ab103435/Anti-DFFB antibody
ab103998/Anti-FOLR2 antibody
ab102831/Anti-DGAT2 antibody
Anti-HAS3透明质酸合成酶3抗体
ab103548/Anti-beta Actin antibody
Anti-FAM3B/PANDER胰腺衍生因子抗体
ab101356/Anti-C12orf41 antibody"
本页产品地址：http://www.geilan.com/sell/show-3244825.html