3060 Phospho-Na,K-ATPase α1 (Tyr10) Antibody #3060

"上海博耀生物销售Phospho-Na,K-ATPase α1 (Tyr10) Antibody #3060，CST原装品质，价格优惠，订购Phospho-Na,K-ATPase α1 (Tyr

"上海博耀生物销售Phospho-Na,K-ATPase α1 (Tyr10) Antibody #3060，CST原装品质，价格优惠，订购Phospho-Na,K-ATPase α1 (Tyr10) Antibody #3060，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Na,K-ATPase α1 (Tyr10) Antibody #3060
货号：3060
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3060S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M (R) (Mk) (B) (Pg)	Endogenous	100	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  B=Bovine  Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Na,K-ATPase α1 (Tyr10) Antibody recognizes endogenous levels of Na,K-ATPase α1 only when phosphorylated at Tyr10. The antibody cross-reacts with an induced 75-80 kDa doublet of unknown origin.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr10 of rat Na,K-ATPase α1. Antibodies are purified using protein A and peptide affinity chromatography.
抗体背景：

The Na,K-ATPase is an integral membrane heterodimer belonging to the P-type ATPase family. This ion channel uses the energy derived from ATP hydrolysis to maintain membrane potential by driving sodium export and potassium import across the plasma membrane against their electrochemical gradients. It is composed of a catalytic α subunit and a β subunit (reviewed in 1). Several phosphorylation sites have been identified for the α1 subunit. Tyr10 is phosphorylated by an as yet undetermined kinase (2), Ser16 and Ser23 are phosphorylated by PKC, and Ser943 is phosphorylated by PKA (3-5). All of these sites have been implicated in the regulation of enzyme activity in response to hormones and neurotransmitters, altering trafficking and kinetic properties of Na,K-ATPase. Altered phosphorylation in response to angiotensin II stimulates activity in the rat proximal tubule (6). Na,K-ATPase is also involved in other signal transduction pathways. Insulin regulates its localization in differentiated primary human skeletal muscle cells, and this regulation is dependent on ERK1/2 phosphorylation of the α subunit (7). Na,K-ATPase and Src form a signaling receptor complex that affects regulation of Src kinase activity and, subsequently, its downstream effectors (8,9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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