3058 DUSP6/MKP3 Antibody #3058

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"上海博耀生物销售DUSP6/MKP3 Antibody #3058，CST原装品质，价格优惠，订购DUSP6/MKP3 Antibody #3058，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：DUSP6/MKP3 Antibody #3058
货号：3058
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3058S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H Mk	Endogenous	48	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： DUSP6/MKP3 Antibody detects endogenous levels of total DUSP6 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human DUSP6. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

MAP kinases are inactivated by dual-specificity protein phosphatases (DUSPs) that differ in their substrate specificity, tissue distribution, inducibility by extracellular stimuli, and cellular localization. DUSPs, also known as MAPK phosphatases (MKP), specifically dephosphorylate both threonine and tyrosine residues in MAPK P-loops and have been shown to play important roles in regulating the function of the MAPK family (1,2). At least 13 members of the family (DUSP1-10, DUSP14, DUSP16, and DUSP22) display unique substrate specificities for various MAP kinases (3). MAPK phosphatases typically contain an amino-terminal rhodanese-fold responsible for DUSP docking to MAPK family members and a carboxy-terminal catalytic domain (4). These phosphatases can play important roles in development, immune system function, stress responses, and metabolic homeostasis (5). In addition, research studies have implicated DUSPs in the development of cancer and the response of cancer cells to chemotherapy (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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