3043 MAPKAPK-3 Antibody #3043

"上海博耀生物销售MAPKAPK-3 Antibody #3043，CST原装品质，价格优惠，订购MAPKAPK-3 Antibody #3043，详情请咨询销售人员！产品

"上海博耀生物销售MAPKAPK-3 Antibody #3043，CST原装品质，价格优惠，订购MAPKAPK-3 Antibody #3043，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：MAPKAPK-3 Antibody #3043
货号：3043
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3043S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H R Mk	Endogenous	42	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： MAPKAPK-3 Antibody detects endogenous levels of total MAPKAPK-3 protein. This antibody does not cross-react with MAPKAPK-2 or -5.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal region of human MAPKAPK-3. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

MAPKAPK-3 has a single potential SH3-binding site in the proline-rich amino terminus, a putative ATP-binding site, 2 MAP kinase phosphorylation site motifs, and a putative nuclear localization signal. It shares 72% nucleotide and 75% amino acid identity with MAPKAPK-2 (1). MAPKAPK-3 has been shown to be activated by growth inducers and stress stimulation of cells. In vitro studies have demonstrated that Erk, p38 MAP kinase, and Jun amino-terminal kinase are able to phosphorylate and activate MAPKAPK-3, which suggested a role for this kinase as an integrative element of signaling in both mitogen and stress responses (2). MAPKAPK-3 was reported to interact with, phosphorylate, and repress the activity of E47, which is a basic helix-loop-helix transcription factor involved in the regulation of tissue-specific gene expression and cell differentiation (3). MAPKAPK-3 may also support luteal maturation through the phosphorylation and activation of the nuclear transcription factor CREB (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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