3023 Phospho-Insulin Receptor β (Tyr1361) (84B2) Rabbit mAb #3023

"上海博耀生物销售Phospho-Insulin Receptor β (Tyr1361) (84B2) Rabbit mAb #3023，CST原装品质，价格优惠，订购Phospho-Insul

"上海博耀生物销售Phospho-Insulin Receptor β (Tyr1361) (84B2) Rabbit mAb #3023，CST原装品质，价格优惠，订购Phospho-Insulin Receptor β (Tyr1361) (84B2) Rabbit mAb #3023，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Insulin Receptor β (Tyr1361) (84B2) Rabbit mAb #3023
货号：3023
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
3023S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H	Transfected Only	95 KDa	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Insulin Receptor β (Tyr1361) (84B2) Rabbit mAb detects transfected levels of insulin receptor β only when phosphorylated at Tyr1361. It slightly cross-reacts with activated IGF-I receptor, but does not cross-react with other activated tyrosine kinases.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1361 of human insulin receptor β.
抗体背景：

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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