3021 Phospho-IGF-I Receptor β (Tyr1131)/Insulin Receptor β (Tyr1146) Antibody #3021

"上海博耀生物销售Phospho-IGF-I Receptor β (Tyr1131)/Insulin Receptor β (Tyr1146) Antibody #3021，CST原装品质，价格优惠

"上海博耀生物销售Phospho-IGF-I Receptor β (Tyr1131)/Insulin Receptor β (Tyr1146) Antibody #3021，CST原装品质，价格优惠，订购Phospho-IGF-I Receptor β (Tyr1131)/Insulin Receptor β (Tyr1146) Antibody #3021，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-IGF-I Receptor β (Tyr1131)/Insulin Receptor β (Tyr1146) Antibody #3021
货号：3021
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3021S	100 ul (10 western blots)	询价
3021L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R (B)	Endogenous	95	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-IGF-I Receptor β (Tyr1131)/Insulin Receptor β (Tyr1146) Antibody detects endogenous levels of Tyr1131-phosphorylated IGF-I receptor and Tyr1146-phosphorylated insulin receptor. The antibody cross-reacts with activated PDGF, FGF and EGF receptors, ErbB2 and c-Met.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues of human IGF-I Receptor β. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-PCDHB7原钙粘蛋白β7抗体
ab103620/Anti-CD18 antibody
Anti-FAM83FFAM83F蛋白抗体
Anti-PCDHGC4原钙粘蛋白γC4抗体
ab102115/Anti-Calumenin antibody
Anti-Neurofascin/Nfasc155神经束蛋白155抗体
Anti-ESYT2/FAM62B延伸突触蛋白2抗体
ab10227/Anti-cardiac Troponin I antibody
ab101450/Anti-CD2 antibody
Anti-PARP多腺苷二磷酸多聚酶抗体/多聚ADP-核糖聚合酶1
ab103878/Anti-CI009 antibody
Anti-CGA/ Chromogranin A嗜铬粒素A抗体
Anti-Trk A/B/C酪氨酸激酶A/B/C抗体
ab103249/Anti-CA13 antibody
Anti-HHV8/ORF50人类疱疹病毒8抗体
ab103608/Anti-CCDC21 antibody"
本页产品地址：http://www.geilan.com/sell/show-3244790.html