3008 DAPK1 Antibody #3008

"上海博耀生物销售DAPK1 Antibody #3008，CST原装品质，价格优惠，订购DAPK1 Antibody #3008，详情请咨询销售人员！产品详细参数

"上海博耀生物销售DAPK1 Antibody #3008，CST原装品质，价格优惠，订购DAPK1 Antibody #3008，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：DAPK1 Antibody #3008
货号：3008
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
3008S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M (R) (Mk)	Endogenous	160	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： DAPK1 Antibody detects endogenous levels of total DAPK1 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly903 of human DAPK1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Death-associated protein kinase (DAPK1) is a Ca²⁺/calmodulin-regulated serine/threonine kinase that participates in a wide range of apoptotic signals including interferon-γ, tumor necrosis factor α, Fas, activated c-Myc, and detachment from the extracellular matrix. In addition to the kinase domain and calmodulin regulatory segment, DAPK1 also has eight ankyrin repeats, a cytoskeleton binding region, and a conserved death domain (1-3). Deletion of the calmodulin-regulatory domain generates a constitutively active mutant kinase. Ectopic expression of wild-type DAPK1 induced cell death in HeLa cells. Conversely, expression of a catalytically inactive mutant protected cells from interferon-γ-induced cell death (4). The catalytic domain of DAPK1 has very high sequence similarity to vertebrate myosin light chain kinase (MLCK) and a RXX(S/T)X motif derived from myosin light chain protein was shown to be phosphorylated in vitro by DAPK1 (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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