2984 Lck (D88) Rabbit mAb #2984

"上海博耀生物销售Lck (D88) Rabbit mAb #2984，CST原装品质，价格优惠，订购Lck (D88) Rabbit mAb #2984，详情请咨询销售人员！

"上海博耀生物销售Lck (D88) Rabbit mAb #2984，CST原装品质，价格优惠，订购Lck (D88) Rabbit mAb #2984，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Lck (D88) Rabbit mAb #2984
货号：2984
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2984P	40 ul (4 western blots)	询价
2984S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IHC-P	H	Endogenous	56	Rabbit IgG

Applications Key:  W=Western Blotting  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Lck (D88) XP^® Rabbit mAb detects endogenous levels of total Lck protein. This antibody does not cross-react with other Src family members.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr50 of human Lck.
抗体背景：

Lck belongs to the Src-like non-receptor tyrosine kinase family with the typical Src family kinase structure: a unique amino terminal domain (Src homology 4 domain, SH4) followed by an SH3 domain, an SH2 domain, a kinase domain (SH1), and a carboxy-terminal negative regulatory domain (1). Lck activity is controlled by the interactions of SH2 and SH3 domains as well as tyrosine phosphorylation status of the activation loop (2,3). Lck is recruited to the T cell receptor (TCR) complex upon stimulation and activates downstream tyrosine kinases to initiate T cell signaling (4). Lck is also found to be involved in the regulation of mitochondrial apoptosis pathways and may be responsible for some anticancer drug induced apoptosis (5,6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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