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Phospho-(Ser)Arg-X-Tyr/Phe-X-pSerMotifAntibody#2981,CST原装品质,价格优惠,订购
Phospho-(Ser)Arg-X-Tyr/Phe-X-pSerMotifAntibody#2981,详情请咨询销售人员!
产品详细参数如下>>>>
产品名称:Phospho-(Ser)Arg-X-Tyr/Phe-X-pSerMotifAntibody#2981
货号:2981
品牌:CST(cell signaling)
抗体来源:Rabbit
克隆类型:
Polyclonal
规格:
| No. |
Size |
Price |
| 2981S |
100ul(10westernblots) |
询价 |
抗体应用:
| Applications |
Reactivity |
Sensitivity |
Source |
| WIPE-P |
All |
Endogenous |
Rabbit |
ApplicationsKey:
W=WesternBlotting
IP=Immunoprecipitation
E-P=ELISA(Peptide)
ReactivityKey:All=Allspeciesexpected
Speciescross-reactivityisdeterminedbywesternblot.
特异性/敏感度:
Phospho-(Ser)Arg-X-Tyr/Phe-X-pSerMotifAntibodydetectsendogenouslevelsofproteinscontainingtheArg-X-Tyr/Phe-X-pSermotif.Thisantibodydoesnotcross-reactwithnonphosphorylatedserineorphospho-threonineproteinswiththesamemotiforotherphospho-serine/threonine-containingproteinsandpeptideswithoutthismotif.(U.S.PatentNo's.:6,441,140;6,982,318;7,259,022;7,344,714;U.S.S.N.11,484,485;andallforeignequivalents.)
来源及纯化方法:
Polyclonal antibodiesareproducedbyimmunizinganimalswithArg-X-Tyr/Phe-X-pSer-containingpeptides.AntibodiesarepurifiedbyproteinAandpeptideaffinitychromatography.
抗体背景:
The14-3-3proteinsareahighlyconservedfamilyofproteinsinvolvedintheregulationofcellsurvival,apoptosis,proliferationandcheckpointcontrol(1-5).Bindingof14-3-3ismediatedthroughphospho-serine-containingproteins(6).Twodifferentphospho-serinecontainingmotifsarefoundusingadegeneratephospho-serine-orientedpeptidelibrarytechnique,RSXS*XPandRXY/FXS*XP(6).Motif2(RXY/FXS*XP)isfoundincriticalregulatoryproteinsincludingcdc2,cdc25B,PKCgamma,IRS-1andBCR(6).AlthoughPhospho-(Ser)Arg-X-Tyr/Phe-X-pSerMotifAntibodybinds14-3-3bindingmotif2withnorequirementforprolineinthe+2position,itprovidesapowerfultoolforthediscoveryandcharacterizationofpotential14-3-3bindingmotif2-containingproteinsorotherproteinswiththeRXY/FXS*motif.
关键词:CST,抗体,一抗{byao_back}{byao_back2}
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