2976 Phospho-mTOR (Ser2448) (49F9) Rabbit mAb (IHC Specific) #2976

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"上海博耀生物销售Phospho-mTOR (Ser2448) (49F9) Rabbit mAb (IHC Specific) #2976，CST原装品质，价格优惠，订购Phospho-mTOR (Ser2448) (49F9) Rabbit mAb (IHC Specific) #2976，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-mTOR (Ser2448) (49F9) Rabbit mAb (IHC Specific) #2976
货号：2976
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2976S	100 ul (50 sections)	询价
2976L	300 ul (150 sections)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
IHC-P IHC-F	H (M) (R)	Endogenous	289	Rabbit IgG

Applications Key:  IHC-P=Immunohistochemistry (Paraffin)  IHC-F=Immunohistochemistry (Frozen)
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-mTOR (Ser2448) (49F9) Rabbit mAb detects endogenous levels of mTOR protein only when phosphorylated at Ser2448.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser2448 of human mTOR.
抗体背景：

The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase (1-3) that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth (4,5). When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1 (6). These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481 (7,8). mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy (9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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