2959 Erlin-2 Antibody #2959

"上海博耀生物销售Erlin-2 Antibody #2959，CST原装品质，价格优惠，订购Erlin-2 Antibody #2959，详情请咨询销售人员！产品详细

"上海博耀生物销售Erlin-2 Antibody #2959，CST原装品质，价格优惠，订购Erlin-2 Antibody #2959，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Erlin-2 Antibody #2959
货号：2959
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2959S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M	Endogenous	43	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Erlin-2 Antibody detects endogenous levels of human erlin-2 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln315 of mouse erlin-2. Antibodies are purified by peptide affinity chromatography.
抗体背景：

Erlin-1 and erlin-2 (SPFH1 and SPFH2) are SPFH domain-containing proteins that belong to the prohibitin family (1,2). The N-termal domain of erlin proteins contains ER-targeting sequences responsible for their translocation to the endoplasmic reticulum (ER) (3). In the ER, erlin-1 and erlin-2 specifically associate with the detergent resistant lipid raft microdomain of the membrane (3). Erlin-1 may be involved in dentritic cell activation (4) and erlin-2 has been shown to regulate the ER-associated degradation (ERAD) pathway by interacting with endogenous substrates and resulting in their polyubiquitination and degradation (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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