2927 Cyclin H Antibody #2927

"上海博耀生物销售Cyclin H Antibody #2927，CST原装品质，价格优惠，订购Cyclin H Antibody #2927，详情请咨询销售人员！产品详

"上海博耀生物销售Cyclin H Antibody #2927，CST原装品质，价格优惠，订购Cyclin H Antibody #2927，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Cyclin H Antibody #2927
货号：2927
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2927P	40 ul (4 western blots)	询价
2927S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R	Endogenous	36	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Cyclin H Antibody detects endogenous levels of cyclin H. It does not cross-react with other family members at physiological levels.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy-terminus of cyclin H. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Cyclin H belongs to a conserved cyclin family that plays a critical role in the regulation of cell cycle dependent kinases (CDKs) necessary for cell cycle progression (1,2). In general, the activity of CDKs requires the binding of appropriate cyclins as well as phosphorylation driven by Cdk-activating kinase (CAK). Cyclin H is part of the CAK complex that includes the kinase CDK7, and an assembly factor p36/Mat1, which enhances binding between cyclin H and CDK7 and increases activity (3,4). CAK regulates progression through the cell cycle by activating cdc2, CDK2, and CDK4 kinases through phosphorylation of a critical threonine residue in the T-loop of the CDK-cyclin complexes (5,6). The CAK complex can exist either in its free form or in association with transcription factor IIH (TFIIH) which can affect its substrate specificity (7,8,9). When bound to TFIIH, CAK preferentially phosphorylates the carboxy-terminal domain of RNA polymerase II (9), providing a link between cell cycle control, transcriptional regulation, and DNA repair.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab103586/Anti-AFF4 antibody
ab101531/Anti-CD44 antibody
ab102548/Anti-CRTAC1 antibody
ab10414/Anti-EGFR antibody
ab103667/Anti-beta II Tubulin antibody
ab102814/Anti-C2GNT3 antibody
ab100988/Anti-Collagen VIII alpha 1 antibody
Anti-alpha 1 Spectrin/Spectrin α血影蛋白/收缩蛋白抗体
Anti-Mfn1线粒体融合蛋白1抗体
ab103718/Anti-FFAR3 antibody
Anti-ERK2/MAPK1丝裂原活化蛋白激酶1抗体
ab103347/Anti-FARS2 antibody
ab102677/Anti-GOSR1 antibody
ab102545/Anti-Glutathione S Transferase kappa 1 antibody
ab101555/Anti-ACBD6 antibody
ab101466/Anti-CFHL1 antibody"
本页产品地址：http://www.geilan.com/sell/show-3244694.html