2922 Cyclin D1 Antibody #2922

"上海博耀生物销售Cyclin D1 Antibody #2922，CST原装品质，价格优惠，订购Cyclin D1 Antibody #2922，详情请咨询销售人员！产品

"上海博耀生物销售Cyclin D1 Antibody #2922，CST原装品质，价格优惠，订购Cyclin D1 Antibody #2922，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Cyclin D1 Antibody #2922
货号：2922
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2922S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R	Endogenous	36	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Cyclin D1 Antibody detects endogenous levels of cyclin D1. It does not cross-react with other family members.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of cyclin D1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Activity of the cyclin-dependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip/Kip or INK family of proteins (1). The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to affect progression through the restriction point and Rb-dependent entry into S-phase (2). The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression (3). Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of protein expression and phosphorylation-dependent degradation (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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