2907 Pim-1 Antibody #2907

"上海博耀生物销售Pim-1 Antibody #2907，CST原装品质，价格优惠，订购Pim-1 Antibody #2907，详情请咨询销售人员！产品详细参数

"上海博耀生物销售Pim-1 Antibody #2907，CST原装品质，价格优惠，订购Pim-1 Antibody #2907，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Pim-1 Antibody #2907
货号：2907
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2907S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H (Mk)	Endogenous	34, 44	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Pim-1 Antibody recognizes endogenous levels of total Pim-1 protein. This antibody does not cross-react with other Pim proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues at the carboxy terminus of human Pim-1. Antibodies were purified by protein A and peptide affinity chromatography.
抗体背景：

Pim proteins (Pim-1, Pim-2 and Pim-3) are oncogene-encoded serine/threonine kinases (1). Pim-1, a serine/threonine kinase highly expressed in hematopoietic cells, plays a critical role in the transduction of mitogenic signals and is rapidly induced by a variety of growth factors and cytokines (1-4). Pim-1 cooperates with c-Myc in lymphoid cell transformation and protects cells from growth factor withdrawal and genotoxic stress-induced apoptosis (5,6). Pim-1 also enhances the transcriptional activity of c-Myb through direct phosphorylation within the c-Myb DNA binding domain as well as phosphorylation of the transcriptional coactivator p100 (7,8). Hypermutations of the Pim-1 gene are found in B-cell diffuse large cell lymphomas (9). Phosphorylation of Pim-1 at Tyr218 by Etk occurs following IL-6 stimulation and correlates with an increase in Pim-1 activity (10). Various Pim substrates have been identified; Bad is phosphorylated by both Pim-1 and Pim-2 at Ser112 and this phosphorylation reverses Bad-induced cell apoptosis (11,12).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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