2906 CDK4 (DCS156) Mouse mAb #2906

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"上海博耀生物销售CDK4 (DCS156) Mouse mAb #2906，CST原装品质，价格优惠，订购CDK4 (DCS156) Mouse mAb #2906，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：CDK4 (DCS156) Mouse mAb #2906
货号：2906
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2906P	40 ul (8 western blots)	询价
2906S	100 ul (20 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M	Endogenous	30	Mouse IgG1

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： CDK4 (DCS156) Mouse mAb detects endogenous levels of total CDK4 protein. The antibody does not cross-react with other CDKs.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with recombinant human CDK4 corresponding to amino acids 270-290.
抗体背景：

Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins (1). The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase (2). The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression (3). In HeLa cells, upon UV irradiation, upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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