2895 CHOP (L63F7) Mouse mAb #2895

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"上海博耀生物销售CHOP (L63F7) Mouse mAb #2895，CST原装品质，价格优惠，订购CHOP (L63F7) Mouse mAb #2895，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：CHOP (L63F7) Mouse mAb #2895
货号：2895
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2895P	40 ul (4 western blots)	询价
2895S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IF-IC	H M R	Endogenous	27	Mouse IgG2a

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： CHOP (L63F7) Mouse mAb detects endogenous levels of total CHOP protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human CHOP.
抗体背景：

CHOP was identified as a C/EBP-homologous protein that inhibits C/EBP and LAP in a dominant-negative manner (1). CHOP expression is induced by certain cellular stresses including starvation and the induced CHOP suppresses cell cycle progression from G1 to S phase (2). Later it was shown that, during ER stress, the level of CHOP expression is elevated and CHOP functions to mediate programmed cell death (3). Studies also found that CHOP mediates the activation of GADD34 and Ero1-Lα expression during ER stress. GADD34 in turn dephosphorylates phospho-Ser51 of eIF2α thereby stimulating protein synthesis. Ero1-Lα promotes oxidative stress inside the endoplasmic reticulum (ER) (4). The role of CHOP in the programmed cell death of ER-stressed cells is correlated with its role promoting protein synthesis and oxidative stress inside the ER (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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