2893 VEGF Receptor 1 Antibody #2893

"上海博耀生物销售VEGF Receptor 1 Antibody #2893，CST原装品质，价格优惠，订购VEGF Receptor 1 Antibody #2893，详情请咨询销

"上海博耀生物销售VEGF Receptor 1 Antibody #2893，CST原装品质，价格优惠，订购VEGF Receptor 1 Antibody #2893，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：VEGF Receptor 1 Antibody #2893
货号：2893
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2893S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	180	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： VEGF Receptor 1 Antibody detects endogenous levels of VEGFR-1. This antibody does not cross-react with VEGFR-2 and -3 nor does it detect the sVEGFR-1 variant.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr1307 of human VEGFR-1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The vascular endothelial growth factor (VEGF) receptor (VEGFR-1, Flt-1) is a 180 kDa receptor tyrosine kinase belonging to the VEGFR (Flt) family (1-3). The receptor is comprised of seven extracellular Ig-like domains, a single transmembrane region and cytoplasmic tail containing the active kinase domain (1,2). VEGFR-1 plays an important role in endothelial cell function and normal vascular development, as well as in hematopoietic function (2,3). VEGF-A is a high affinity ligand of VEGFR-1. VEGFR-1 also binds VEGF-B and PLGF (2). Ligand binding results in very little VEGFR-1 kinase activation, and VEGFR-1/VEGF-A binding negatively regulates VEGF function by diverting the growth factor from other functional VEGF receptors (3).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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