2889 Notch3 Antibody #2889

"上海博耀生物销售Notch3 Antibody #2889，CST原装品质，价格优惠，订购Notch3 Antibody #2889，详情请咨询销售人员！产品详细参

"上海博耀生物销售Notch3 Antibody #2889，CST原装品质，价格优惠，订购Notch3 Antibody #2889，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Notch3 Antibody #2889
货号：2889
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2889S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H	Endogenous	90, 270	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Notch3 Antibody detects endogenous levels of total Notch3 protein. It recognizes the full-length (270 kDa) and the extracellular truncated fragment containing a short extracellular region, the transmembrane domain and the intracellular region (90 kDa).
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro2311 of human notch3. Antibodies were purified by protein A and peptide affinity chromatography.
抗体背景：

Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) (2). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes (3-4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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