2877 FE65 Antibody #2877

"上海博耀生物销售FE65 Antibody #2877，CST原装品质，价格优惠，订购FE65 Antibody #2877，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售FE65 Antibody #2877，CST原装品质，价格优惠，订购FE65 Antibody #2877，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：FE65 Antibody #2877
货号：2877
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2877S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	M R (H)	Endogenous	100	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： FE65 Antibody detects endogenous levels of FE65. It does not cross-react with FE65L1 or FE65L2.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues of human FE65. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

FE65, FE65L1 and FE65L2 are members of the FE65 protein family. FE65 is an adaptor protein with protein-protein interaction domains including a WW domain followed by two phosphotyrosine interaction domains (PID1 and PID2) (1). Amyloid beta precursor protein (APP) binds to PID2 and undergoes sequential cleavage. First alpha-/beta secretases cleave and release the ectodomain into the extracellular environment. Subsequent processing by the gamma-secretase complex results in the APP intracellular domain (AICD) and the beta-amyloid peptides. The latter A-beta fragments form the main components of amyloid plaques in patients with Alzheimer's disease (2). FE65 family members can regulate APP processing, resulting in elevated levels of A-beta (3). Double knock-out mice of FE65 and FE65L1 display a phenotype that occurs in animals lacking APP family members, supporting a functional interaction between FE65 and APP (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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