2849 β-Catenin (L54E2) Mouse mAb (Alexa Fluor 488 Conjugate) #2849

"上海博耀生物销售β-Catenin (L54E2) Mouse mAb (Alexa Fluor 488 Conjugate) #2849，CST原装品质，价格优惠，订购β-Catenin (

"上海博耀生物销售β-Catenin (L54E2) Mouse mAb (Alexa Fluor 488 Conjugate) #2849，CST原装品质，价格优惠，订购β-Catenin (L54E2) Mouse mAb (Alexa Fluor 488 Conjugate) #2849，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：β-Catenin (L54E2) Mouse mAb (Alexa Fluor 488 Conjugate) #2849
货号：2849
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2849S	100 ul (50 tests)	询价

抗体应用：

Applications	Reactivity	Sensitivity	Isotype
IF-F IF-IC F	H R (M) (Mk) (Pg)	Endogenous	Mouse IgG1

Applications Key:  IF-F=Immunofluorescence (Frozen)  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： β-Catenin (L54E2) Mouse mAb (Alexa Fluor^® 488 Conjugate) detects endogenous levels of total β-catenin protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human β-catenin. The antibody was conjugated to Alexa Fluor^® 488 under optimal conditions with an F/P ratio of 2-5.
抗体背景：

β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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