2814 RecQ4 Antibody #2814

"上海博耀生物销售RecQ4 Antibody #2814，CST原装品质，价格优惠，订购RecQ4 Antibody #2814，详情请咨询销售人员！产品详细参数

"上海博耀生物销售RecQ4 Antibody #2814，CST原装品质，价格优惠，订购RecQ4 Antibody #2814，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：RecQ4 Antibody #2814
货号：2814
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2814S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H R (Mk)	Endogenous	150	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： RecQ4 Antibody detects endogenous levels of total RecQ4 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids near the amino terminus of human RecQ4. Antibodies are purified by peptide affinity chromatography.
抗体背景：

RECQL4 is a member of the RecQ family of DNA helicases that plays an important role in global genomic stability. There are five members of this family in humans, and mutations in three of these, BLM, WRN and RECQL4, give rise to disorders that are characterized by premature aging and a predisposition to cancer (1). Despite the presence of a helicase domain, no helicase activity has been reported for RECQL4. Rather, RECQL4 has an ATPase function that is stimulated by ssDNA, and a ssDNA annealing activity that is inhibited by RPA (2). RECQL4 has been reported to interact with ubiquitin ligases UBR1 and UBR2 (3). The role of RECQL4 in tumor suppression and the maintenance of genomic integrity has been attributed to it’s activities associated with the regulation of DNA replication, and DNA recombination and repair (4-6).Mutations in the RECQL4 gene have been identified in a subset of patients with Rothmund-Thomson syndrome (RTS) - a disorder characterized by growth deficiency, skin and skeletal abnormalities, and cancer predisposition. Two more autosomal recessive disorders have been associated with RECQL4 gene mutations: RAPADILINO, and Baller-Gerold syndromes (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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