2803 Survivin Antibody #2803

"上海博耀生物销售Survivin Antibody #2803，CST原装品质，价格优惠，订购Survivin Antibody #2803，详情请咨询销售人员！产品详

"上海博耀生物销售Survivin Antibody #2803，CST原装品质，价格优惠，订购Survivin Antibody #2803，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Survivin Antibody #2803
货号：2803
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2803S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H	Endogenous	16	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Surivivin Antibody detects endogenous levels of total human survivin. The antibody does not cross-react with other types of apoptotic inhibitor proteins at physiological conditions.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyl terminus of human survivin. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy (1). Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division (2,3). This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase (4). Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth (5,6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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