2792 Tyrosine Hydroxylase Antibody #2792

"上海博耀生物销售Tyrosine Hydroxylase Antibody #2792，CST原装品质，价格优惠，订购Tyrosine Hydroxylase Antibody #2792，详

"上海博耀生物销售Tyrosine Hydroxylase Antibody #2792，CST原装品质，价格优惠，订购Tyrosine Hydroxylase Antibody #2792，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Tyrosine Hydroxylase Antibody #2792
货号：2792
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2792S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IF-IC	M R	Endogenous	55-60	Rabbit

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Tyrosine Hydroxylase Antibody detects endogenous levels of total tyrosine hydroxylase.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human tyrosine hydroxylase. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms (1,2). This enzyme is required for embryonic development since TH knockout mice die before or at birth (3). Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH (4-6). Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels (7-9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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