2789 Adiponectin (C45B10) Rabbit mAb #2789

"上海博耀生物销售Adiponectin (C45B10) Rabbit mAb #2789，CST原装品质，价格优惠，订购Adiponectin (C45B10) Rabbit mAb #2789

"上海博耀生物销售Adiponectin (C45B10) Rabbit mAb #2789，CST原装品质，价格优惠，订购Adiponectin (C45B10) Rabbit mAb #2789，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Adiponectin (C45B10) Rabbit mAb #2789
货号：2789
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2789S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	M R (H)	Endogenous	27	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Adiponectin (C45B10) Rabbit mAb detects endogenous levels of total adiponectin protein monomer. It will not detect higher molecular weight forms of adiponectin.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to human adiponectin.
抗体背景：

Adiponectin, also termed AdipoQ, Acrp30, apM1 and GBP28, is an adipokine expressed exclusively in brown and white adipocytes (1). It is secreted into the blood and exists in three major forms: a low molecular weight trimer, a medium molecular weight hexamer and a high molecular weight multimer (1). Adiponectin levels are decreased in obese and insulin-resistant mice and humans (2), suggesting that this adipokine is critical to maintain insulin sensitivity. Adiponectin stimulates the phosphorylation of AMPKα at Thr172 and activates AMPK in skeletal muscle (3). It also stimulates glucose uptake in myocytes (3). The block of AMPK activation by a dominant-negative AMPKα2 isoform inhibits the effect of adiponectin on glucose uptake, indicating that adiponectin stimulates glucose uptake and increases insulin sensitivity through its action on AMPK (3). Adiponectin mutants that are not able to form oligomers larger than trimers have no effect on the AMPK pathway (4). Mutations that render adiponectin unable to form high molecular weight multimers are associated with human diabetes (4), indicating the importance of multimerization for adiponectin activity.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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