2761 Numb (C44B4) Rabbit mAb #2761

"上海博耀生物销售Numb (C44B4) Rabbit mAb #2761，CST原装品质，价格优惠，订购Numb (C44B4) Rabbit mAb #2761，详情请咨询销售

"上海博耀生物销售Numb (C44B4) Rabbit mAb #2761，CST原装品质，价格优惠，订购Numb (C44B4) Rabbit mAb #2761，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Numb (C44B4) Rabbit mAb #2761
货号：2761
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2761S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IF-IC F	H	Endogenous	72, 74	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Numb (C44B4) Rabbit mAb detects endogenous levels of Numb protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe482 of human Numb protein.
抗体背景：

Numb contains an amino-terminal phosphotyrosine-binding (PTB) domain and carboxy-terminal endocytic binding motifs for α-adaptin and EH (Eps15 homology) domain-containing proteins, indicating a role in endocytosis (1,2). There are four mammalian Numb splicing isoforms that are differentially expressed and may have distinct functions (3-5). Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch (6). The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates (7,8). The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling (9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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