2755 Fgr Antibody #2755

"上海博耀生物销售Fgr Antibody #2755，CST原装品质，价格优惠，订购Fgr Antibody #2755，详情请咨询销售人员！产品详细参数如下

"上海博耀生物销售Fgr Antibody #2755，CST原装品质，价格优惠，订购Fgr Antibody #2755，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Fgr Antibody #2755
货号：2755
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2755S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP F	H	Endogenous	56	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  F=Flow Cytometry
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Fgr Antibody detects endogenous levels of total Fgr proteins. This antibody does not cross-react with other proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues close to the amino terminus of human Fgr. Antibodies are purified by protein A and peptide affinity chromatography.  
抗体背景：

Fgr is a member of the Src tyrosine kinase family. It has a membrane-associated amino-terminal domain that is highly divergent from other family members, internal conserved SH2 and SH3 domains and a highly conserved carboxy-terminal tyrosine kinase catalytic domain (1,2). Tyrosine 412 is located in the activation loop, and phosphorylation of this residue is critical for the activation of Fgr tyrosine kinase activity. c-Fgr is predominantly expressed in cells of hematopoietic origin including differentiated myeloid cells, NK and B cells (3,4). Fgr plays an important role in the signaling cascade from membrane receptors lacking intrinsic tyrosine kinase activity such as Bcr, FcR, and the integrin family of receptors (5). It was demonstrated that Fgr functions as a selective inhibitor of beta2 integrin-mediated signaling and Syk kinase function in monocytes (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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