2753 Ku80 Antibody #2753

"上海博耀生物销售Ku80 Antibody #2753，CST原装品质，价格优惠，订购Ku80 Antibody #2753，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售Ku80 Antibody #2753，CST原装品质，价格优惠，订购Ku80 Antibody #2753，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Ku80 Antibody #2753
货号：2753
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2753S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP IHC-P IF-IC F	H Mk (M) (R)	Endogenous	86	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Ku80 antibody detects endogenous levels of total Ku80 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human Ku80. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Ku is a heterodimeric protein composed of two subunits (Ku70 and Ku80) originally identified by researchers as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis, and systemic lupus erythematosus (1). Ku is an abundant, ubiquitously expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks (2-5). The Ku70/Ku80 heterodimer has ATP-dependent DNA helicase activity and functions as the DNA-binding regulatory component of DNA-dependent protein kinase (DNA-PK) (6-8). The assembly of the DNA-PK complex at DNA ends is required for nonhomologous end-joining (NHEJ), one mechanism involved in double-stranded DNA break repair and V(D)J recombination (8). DNA-PK has been shown to phosphorylate many proteins, including p53, serum response factor, c-Jun, c-Fos, c-Myc, Oct-1, Sp-1, and RNA polymerase II (1,8). The combined activities of Ku70/Ku80 and DNA-PK implicate Ku in many cellular functions, including cell cycle regulation, DNA replication and repair, telomere maintenance, recombination, and transcriptional activation.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-MRP3多药耐药相关蛋白3抗体
ab103883/Anti-ATXN10 antibody
Anti-GAPDH3-磷酸甘油醛脱氢酶（兔来源免疫组化用抗体）
Anti-IDE胰岛素降解酶抗体
ab101344/Anti-Genethonin 1 antibody
Anti-OTOA/DFNB22耳聋、常染色体隐性遗传22抗体
ab101974/Anti-CLUL1 antibody
ab102926/Anti-Dio3 antibody
Anti-ER-Alpha雌激素受体α抗体（用于western blot）
ab103155/Anti-FGFR1 antibody
ab102819/Anti-C1orf41 antibody
ab101465/Anti-EFHA1 antibody
ab101012/Anti-DR4 antibody
Anti-AcinusAcinus抗体
Anti-MYBPC1肌球蛋白结合蛋白C抗体
ab103662/Anti-CT054 antibody"
本页产品地址：http://www.geilan.com/sell/show-3244556.html