2743 ISG15 Antibody #2743

"上海博耀生物销售ISG15 Antibody #2743，CST原装品质，价格优惠，订购ISG15 Antibody #2743，详情请咨询销售人员！产品详细参数

"上海博耀生物销售ISG15 Antibody #2743，CST原装品质，价格优惠，订购ISG15 Antibody #2743，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：ISG15 Antibody #2743
货号：2743
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2743S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W F E-P	H M Mk	Endogenous	15	Rabbit

Applications Key:  W=Western Blotting  F=Flow Cytometry  E-P=ELISA (Peptide)
Reactivity Key:  H=Human  M=Mouse  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： This antibody detects endogenous levels of both free and conjugated ISG15 protein. The antibody does not cross-react with other ubiquitin family members, including ubiquitin, SUMO1, SUMO2, SUMO3 and NEDD8.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids from human ISG15 protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Interferon-stimulated 15 kDa protein (ISG15), also known as ubiquitin cross-reactive protein (UCRP), is a member of the ubiquitin-like protein family and functions in various biological pathways from pregnancy to innate immune responses (1). Expression of ISG15 is stimulated by cellular exposure to type 1 interferons α and β, in addition to infection with viruses such as influenza B (2,3). After exposure to type I interferons, both lymphocytes and monocytes, in addition to some fibroblasts and epithelial cells, release ISG15 into culture medium (1,4). ISG15 has been shown to function as a cytokine, stimulating interferon γ secretion by monocytes and macrophages, proliferation of natural killer cells, and chemotactic responses in neutrophils (4,5). ISG15 has also been shown to function intracellularly, being covalently conjugated to other proteins by E1 (Ube1L), E2 (UbcH8) and E3 ligases via a multi-step process analogous to ubiquitination (6,7). ISG15 is removed from proteins by the ubiquitin processing protease Ubp43 (8). ISG15-protein conjugation (ISGylation) is induced by type 1 interferons, and target proteins include the serine protease inhibitor Serpin 2A, PLCγ1, ERK1/2, Jak1 and Stat1 (9,10). Unlike ubiquitination, ISGylation does not target proteins for degradation, rather ISGylation increases Jak1 and Stat1 activity, enhancing the cellular response to interferons (11).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab10362/Anti-DNA Polymerase delta, catalytic subunit antibody
Anti-ADAMTS7(NT)整合素样金属蛋白酶与凝血酶1型-7抗体 (N端抗体)
ab101429/Anti-C3IP1 antibody
Anti-BRCA1/BAP1乳腺癌易感基因1抗体
ab10286/Anti-Calnexin - ER membrane marker antibody
ab10034/Anti-Corticotropin Releasing Factor antibody
ab103077/Anti-FANCI antibody
ab103974/Anti-ARF5 antibody
Anti-CD44/HCAM/PGP1CD44抗体
Anti-caspase-3 p12 subunit活化半胱胺酸蛋白酶蛋白-3抗体
Anti-IFN-Beta干扰素β抗体
ab103877/Anti-FKBPL antibody
Anti-Desmin/DES结蛋白抗体
Anti-Cyclin C周期素C抗体
Anti-Nox4/NADHNADPH氧化酶4抗体
ab102479/Anti-CYPIVF11 antibody"
本页产品地址：http://www.geilan.com/sell/show-3243798.html