2733 Numb Antibody #2733

"上海博耀生物销售Numb Antibody #2733，CST原装品质，价格优惠，订购Numb Antibody #2733，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售Numb Antibody #2733，CST原装品质，价格优惠，订购Numb Antibody #2733，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Numb Antibody #2733
货号：2733
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2733S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	72, 74	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Numb Antibody detects endogenous levels of total Numb protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe482 of human Numb. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Numb contains an amino-terminal phosphotyrosine-binding (PTB) domain and carboxy-terminal endocytic binding motifs for α-adaptin and EH (Eps15 homology) domain-containing proteins, indicating a role in endocytosis (1,2). There are four mammalian Numb splicing isoforms that are differentially expressed and may have distinct functions (3-5). Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch (6). The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates (7,8). The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling (9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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