2732 Lyn Antibody #2732

"上海博耀生物销售Lyn Antibody #2732，CST原装品质，价格优惠，订购Lyn Antibody #2732，详情请咨询销售人员！产品详细参数如下

"上海博耀生物销售Lyn Antibody #2732，CST原装品质，价格优惠，订购Lyn Antibody #2732，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Lyn Antibody #2732
货号：2732
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2732S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R	Endogenous	56	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Lyn Antibody detects endogenous levels of the 56 kDa isoform of Lyn. It does not recognize the 53 kDa Lyn isoform.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human Lyn. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells (1). Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivalent to Tyr416 of Src), located in the catalytic domain, correlates with enzyme activation. Csk-mediated phosphorylation of the carboxy-terminal Tyr507 (equivalent to Tyr527 of Src) inactivates the kinase. Tyrosine phosphorylation and activation of Lyn occurs upon association with cell surface receptors such as the B cell Ag receptor (BCR) and CD40 (2-4). Studies using knockout mice have shown that the net effect of Lyn deficiency is to render B cells hypersensitive to BCR stimulation (5-7), suggesting that the most critical role for Lyn in vivo is in the down-regulation of B cell responses. Lyn is also involved in controlling the migration and development of specific B cell populations (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-DISC1(NT)DISC1 N端抗体
ab102042/Anti-Gemin 7 antibody
Anti-VEGF血管内皮生长因子抗体
Anti-TRT/TERT端粒酶反转录酶抗体
ab104278/Anti-EFHC1 antibody
ab101829/Anti-BPIL3 antibody
Anti-NR2C/NMDAR2C谷氨酸受体2C抗体（N端）
Anti-PAX3配对盒基因3抗体
ab103434/Anti-C19orf18 antibody
Anti-Myelin PLP髓磷酯髓鞘蛋白1抗体
Anti-Nm23-H2肿瘤抑制基因抗体
ab10067/Anti-Fibrinogen antibody
ab102545/Anti-Glutathione S Transferase kappa 1 antibody
ab100890/Anti-AGPAT1 antibody
Anti-BGP/Osteocalcin骨保护蛋白/骨钙素抗体
ab101859/Anti-CPLX3 antibody"
本页产品地址：http://www.geilan.com/sell/show-3243790.html