2728 SHIP1 (D1163) Antibody #2728

"上海博耀生物销售SHIP1 (D1163) Antibody #2728，CST原装品质，价格优惠，订购SHIP1 (D1163) Antibody #2728，详情请咨询销售人

"上海博耀生物销售SHIP1 (D1163) Antibody #2728，CST原装品质，价格优惠，订购SHIP1 (D1163) Antibody #2728，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：SHIP1 (D1163) Antibody #2728
货号：2728
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2728S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M (R)	Endogenous	145	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： SHIP1 (D1163) Antibody detects the endogenous levels of total SHIP1 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp1163 of human SHIP1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate (1). SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus (1,2). Upon receptor cross-linking, SHIP is first recruited to the membrane junction through binding of its SH2 domain to the phospho-tyrosine in the ITIM motif (2), followed by tyrosine phosphorylation on the NPXY motif (2). The membrane relocalization and phosphorylation on the NPXY motif is essential for the regulatory function of SHIP1 (3-5). Its effect on calcium flux, cell survival, growth, cell cycle arrest and apoptosis is mediated through the PI3K and Akt pathways (3-5). Tyr1021 is located in one of the NPXY motifs in SHIP1, and its phosphorylation is important for SHIP1 function (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab101965/Anti-ARHGAP30 antibody
Anti-KLF4肠道内富含的Kruppel样因子/上皮锌指蛋白4抗体
Anti-Spindlin 1卵巢癌相关蛋白抗体
Anti-NLGN2神经连接蛋白2抗体
ab103155/Anti-FGFR1 antibody
Anti-PCDHGA5原钙粘蛋白γA5抗体
Anti-Annexin V重组膜粘连蛋白5抗体
Anti-phospho-Tau protein(Ser733)磷酸化微管相关蛋白抗体
Anti-C5a过敏毒素C5a（补体C5a）抗体
Anti-TRAILR1/DR4/APO2死亡受体4抗体
ab103661/Anti-C17orf49 antibody
Anti-Activated protein C/PROC1活化蛋白C抗体
ab101655/Anti-AEBP2 antibody
ab100927/Anti-DUSP22 antibody
ab101466/Anti-CFHL1 antibody
ab101461/Anti-FKBP7 antibody"
本页产品地址：http://www.geilan.com/sell/show-3243786.html