2694 Phospho-IKKα/β (Ser176/180) Antibody II #2694

"上海博耀生物销售Phospho-IKKα/β (Ser176/180) Antibody II #2694，CST原装品质，价格优惠，订购Phospho-IKKα/β (Ser176/18

"上海博耀生物销售Phospho-IKKα/β (Ser176/180) Antibody II #2694，CST原装品质，价格优惠，订购Phospho-IKKα/β (Ser176/180) Antibody II #2694，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-IKKα/β (Ser176/180) Antibody II #2694
货号：2694
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2694P	40 ul (4 western blots)	询价
2694S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R Mk	Endogenous	85 IKK-alpha 87 IKK-beta	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-IKKα/β (Ser176/180) Antibody II detects endogenous levels of IKKα and IKKβ only when phosphorylated at Ser176 and Ser180 or Ser177 and Ser181, respectively.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a phosphopeptide corresponding to a region surrounding Ser177/181 of IKKβ. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3). Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit (8,9). Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation (10-13).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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