2671 4F2hc/CD98 Antibody #2671

"上海博耀生物销售4F2hc/CD98 Antibody #2671，CST原装品质，价格优惠，订购4F2hc/CD98 Antibody #2671，详情请咨询销售人员！产

"上海博耀生物销售4F2hc/CD98 Antibody #2671，CST原装品质，价格优惠，订购4F2hc/CD98 Antibody #2671，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：4F2hc/CD98 Antibody #2671
货号：2671
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2671S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M Mk	Endogenous	75-120	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： 4F2hc/CD98 Antibody recognizes endogenous levels of total 4F2hc/CD98 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg524 of human 4F2hc/CD98 protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

4F2hc is a transmembrane protein that belongs to the solute carrier family. 4F2hc forms heterodimeric complexes with various amino acid transporters such as LAT1 and LAT2 and regulates uptake of amino acids (1-5). 4F2hc is one of the earliest expressed antigens on the surface of activated human lymphocytes (6), hence it is also named CD98. 4F2hc is expressed in all cell types with the exception of platelets, and is expressed at highest levels in the tubules of the kidney and the gastrointestinal tract (7,8). It is localized at the plasma membrane when associated with LAT1 or LAT2 (9) and at the apical membrane of placenta (10). Research studies have shown that 4F2hc is highly expressed in various tumors including glioma (11), ovarian cancer (12), and astrocytomas (13), and it has been implicated in tumor progression and correlated with poor outcome in patients with pulmonary neuroendocrine tumors (14). 4F2hc is also involved in integrin trafficking through association with β1 and β4 integrins, and regulates keratinocyte adhesion and differentiation (15).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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