2662 Chk2 Antibody #2662

"上海博耀生物销售Chk2 Antibody #2662，CST原装品质，价格优惠，订购Chk2 Antibody #2662，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售Chk2 Antibody #2662，CST原装品质，价格优惠，订购Chk2 Antibody #2662，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Chk2 Antibody #2662
货号：2662
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2662P	40 ul (4 western blots)	询价
2662S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R Mk	Endogenous	62	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Chk2 Antibody detects endogenous levels of total Chk2 protein independent of phosphorylation.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino-terminus of human Chk2.
抗体背景：

Chk2 is the mammalian orthologue of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases (1-3). The amino-terminal domain of Chk2 contains a series of seven serine or threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50, and Thr68) each followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases (4,5). After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR (5-7). The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 at residues Thr383 and Thr387 in the activation loop of the kinase domain (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab101570/Anti-ACSS1 antibody
ab103824/Anti-EFHC1 antibody
ab104224/Anti-FOX3/NeuN antibody
ab10237/Anti-cardiac Troponin I antibody
ab103472/Anti-CD75 antibody
Anti-Nestin巢蛋白/神经上皮干细胞蛋白抗体
ab100868/Anti-AADACL4 antibody
ab102655/Anti-ANKRD5 antibody
ab102730/Anti-CTLA4 antibody
ab100872/Anti-ABP1 antibody
Anti-CD25/IL-2RA白介素2受体a链抗体 IL-2Ra
ab101575/Anti-GTPBP9 antibody
Anti-CD79A/IGBP-1免疫球蛋白结合蛋白-1抗体
ab103543/Anti-ASMTL antibody
Anti-IFITM1/CD225干扰素诱导跨膜蛋白1抗体
ab101736/Anti-G protein alpha S antibody"
本页产品地址：http://www.geilan.com/sell/show-3243725.html