2655 CK1 Antibody #2655

"上海博耀生物销售CK1 Antibody #2655，CST原装品质，价格优惠，订购CK1 Antibody #2655，详情请咨询销售人员！产品详细参数如下

"上海博耀生物销售CK1 Antibody #2655，CST原装品质，价格优惠，订购CK1 Antibody #2655，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：CK1 Antibody #2655
货号：2655
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2655S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R (C) (X) (Z) (B)	Endogenous	34	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  C=Chicken  X=Xenopus  Z=Zebrafish  B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： This antibody detects endogenous levels of total casein kinase I-alpha 1 protein. This antibody may cross-react with casein kinase I-epsilon, casein kinase I-delta, and casein kinase I-gamma.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acid residues near the middle of human casein kinase I-alpha 1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

CK1 (Casein Kinase I or CKI) is the name given to a family of kinases consisting of multiple isoforms (alpha, alpha-prime, beta, gamma1-3, delta, and epsilon) with a conserved N-terminal kinase domain and a variable C-terminal sequence that determines subcellular localization and regulates enzyme activity (1-3). Indeed, multiple inhibitory autophosphorylation sites have been identified near the C-terminus of (CKI-epsilon) (3). This ubiquitously expressed family of protein kinases has been implicated in multiple processes including DNA repair, cell morphology, and Wnt signaling (4). Perhaps the best understood role of CKI is to provide the priming phosphorylation of beta-catenin at Ser45 to produce the consensus GSK-3 substrate motif (Ser/Thr-X-X-X-Phospho-Ser) (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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